Solved! For this assignment, choose a scholarly article containing a research study discussing the efficacy of a psychiatric treatment
For this assignment, choose a scholarly article containing a research study discussing the efficacy of a psychiatric treatment
For this assignment, choose a scholarly article containing a research study discussing the efficacy of a psychiatric treatment. You can research a specific medication, a diagnostic rating scale, TMS, ECT, an integrative or alternative treatment (e.g., MDMA, psychedelics, an herbal supplement, etc.), or a medication augmentation strategy that is used in psychiatry. In your Initial post:- Discuss the research study purpose, population, and how the study was conducted.
- Explain the study findings and recommendations.
- Analyze and discuss strengths and weaknesses of the study and whether you think the research supports the use of this intervention.
- Support your opinion with at least one additional scholarly article.
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Sample Expert Answer
Research Overview Discussion Board
Research Study Purpose, Population, and Study Design
The research study by Sackeim et al. (2020) aimed to evaluate the efficacy of Transcranial Magnetic Stimulation (TMS) as a treatment for Major Depressive Disorder (MDD) in a real-world clinical setting. TMS has been recognized as an effective treatment for MDD in randomized clinical trials, particularly for treatment-resistant cases. However, there is a need to better understand its efficacy in routine clinical practice, as well as to identify predictors of positive outcomes based on patient characteristics and treatment factors.
The study’s population consisted of 7,759 adult patients from 103 practice sites, with the intent-to-treat (ITT) sample including 5,010 individuals aged 18 or older, all diagnosed with MDD (Sackeim et al., 2020). The study used patient-rated (PHQ-9) and clinician-rated (CGI-S) clinical outcomes to assess treatment efficacy, measuring response and remission rates.
The study was conducted by collecting data from a registry that utilized the NeuroStar® Advanced Therapy System Clinical Outcomes Registry. Participants were required to complete a PHQ-9 assessment (a self-reported measure of depression severity) both before and after TMS treatment. Those included in the “completer” group had either responded to the treatment or completed 20 or more sessions with a final PHQ-9 assessment at the end of acute treatment (Sackeim et al., 2020). The clinician-rated CGI-S assessments were conducted for a smaller subset of participants.
Study Findings and Recommendations
The study reported highly favorable outcomes for TMS treatment in patients with MDD. Among the intent-to-treat (ITT) group, the response rates ranged between 58% and 83%, while the remission rates varied between 28% and 62%. These results were significant across both self-reported (PHQ-9) and clinician-administered (CGI-S) assessments (Sackeim et al., 2020). Certain factors were identified as predictors of more favorable outcomes.
For example, female patients and those who received a higher number of magnetic pulses per session exhibited superior clinical outcomes compared to others. Despite the voluntary participation of sites and the open-label design, the findings indicated that TMS had substantial clinical benefits in routine practice, comparable to or exceeding those of alternative treatments for treatment-resistant depression.
Strengths and Weaknesses of the Study
One of the primary strengths of this study is its large sample size, with over 7,000 participants contributing to robust and generalizable findings (Sackeim et al., 2020). Additionally, the use of real-world clinical data provides valuable insight into the practical application of TMS outside of controlled clinical trials, making the results highly relevant for healthcare providers who are considering TMS as a treatment option for their patients with MDD.
The inclusion of both self-reported and clinician-reported outcomes enhances the reliability of the findings by capturing multiple perspectives on treatment efficacy. The study also had several notable weaknesses (Sackeim et al., 2020). The voluntary participation of sites and the open-label design could introduce biases, as the healthcare providers involved may have had a vested interest in reporting positive outcomes.
Analysis
Overall, there is strong evidence supporting the use of TMS in treating MDD, particularly for patients who have not responded well to traditional treatments (Sackeim et al., 2020; Thompson, 2020). The significant response and remission rates observed in both self-reported and clinician-assessed outcomes suggest that TMS is a valuable treatment option for reducing depressive symptoms.
The study’s findings align with previous research on TMS, further validating its effectiveness in both clinical trials and real-world practice (Sackeim et al., 2020; Thompson, 2020). Future research should focus on addressing these limitations by conducting randomized controlled trials in real-world settings and examining the long-term effects of TMS.
References
Sackeim, H. A., Aaronson, S. T., Carpenter, L. L., Hutton, T. M., Mina, M., Pages, K., Verdoliva, S., & West, W. S. (2020). Clinical outcomes in a large registry of patients with major depressive disorder treated with Transcranial Magnetic Stimulation. Journal of Affective Disorders, 277, 65-74. https://doi.org/10.1016/j.jad.2020.08.005
Thompson, L. (2020). Treating major depression and comorbid disorders with transcranial magnetic stimulation. Journal of Affective Disorders, 276, 453-460. https://doi.org/10.1016/j.jad.2020.07.025
